Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)

Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation, also known as lbsl, is related to cone-rod dystrophy 2 and leukodystrophy, and has symptoms including ataxia, muscle spasticity and tremor. An important gene associated with Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation is DARS2 (Aspartyl-TRNA Synthetase 2, Mitochondrial). Affiliated tissues include spinal cord and brain, and related phenotypes are abnormality of the dorsal column of the spinal cord and dysarthria