Leukodystrophy, Progressive, Early Childhood-Onset (PLDECO)

Leukodystrophy, Progressive, Early Childhood-Onset, also known as alkaline ceramidase 3 deficiency, is related to aceruloplasminemia and colitis. An important gene associated with Leukodystrophy, Progressive, Early Childhood-Onset is ACER3 (Alkaline Ceramidase 3). Affiliated tissues include brain, and related phenotypes are developmental regression and coarse facial features