Leukodystrophy, Hypomyelinating, 11 (HLD11)

Leukodystrophy, Hypomyelinating, 11, also known as hypomyelinating leukodystrophy 11, is related to polr3-related leukodystrophy and spastic paraplegia 25, autosomal recessive. An important gene associated with Leukodystrophy, Hypomyelinating, 11 is POLR1C (RNA Polymerase I And III Subunit C), and among its related pathways/superpathways are RNA Polymerase III Transcription Initiation and Cytosolic sensors of pathogen-associated DNA. Affiliated tissues include brain and peripheral nerve, and related phenotypes are ataxia and tremor