Legius Syndrome (LGSS)

Legius Syndrome, also known as neurofibromatosis type 1-like syndrome, is related to noonan syndrome 1 and noonan syndrome with multiple lentigines. An important gene associated with Legius Syndrome is SPRED1 (Sprouty Related EVH1 Domain Containing 1), and among its related pathways/superpathways are Development EPO-induced Jak-STAT pathway and MAP Kinase Signaling. Affiliated tissues include skin and lung, and related phenotypes are multiple cafe-au-lait spots and specific learning disability