Krabbe Disease (KRB)

Krabbe Disease, also known as globoid cell leukodystrophy, is related to infantile krabbe disease and leukodystrophy, and has symptoms including seizures, vomiting and hyperirritability. An important gene associated with Krabbe Disease is GALC (Galactosylceramidase), and among its related pathways/superpathways are Metabolism and IL-1 Family Signaling Pathways. The drugs Prednisolone and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain and eye, and related phenotypes are progressive spasticity and reduced galactocerebrosidase activity