Kleefstra Syndrome 2, also known as klefs2, is related to kleefstra syndrome and autism. An important gene associated with Kleefstra Syndrome 2 is KMT2C (Lysine Methyltransferase 2C), and among its related pathways/superpathways are Chromatin organization and PKMTs methylate histone lysines. Affiliated tissues include eye and breast, and related phenotypes are intellectual disability and seizure