Juvenile Rheumatoid Arthritis (JIA)

Juvenile Rheumatoid Arthritis, also known as juvenile idiopathic arthritis, is related to rheumatoid factor-negative polyarticular juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Juvenile Rheumatoid Arthritis is IL6 (Interleukin 6), and among its related pathways/superpathways are ERK Signaling and Innate Immune System. The drugs Leflunomide and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and endocrine/exocrine gland