Juvenile Myelomonocytic Leukemia (JMML)

Juvenile Myelomonocytic Leukemia, also known as leukemia, juvenile myelomonocytic, is related to noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia and noonan syndrome 3, and has symptoms including exanthema, fatigue and fever. An important gene associated with Juvenile Myelomonocytic Leukemia is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Infectious disease and ERK Signaling. The drugs Omacetaxine mepesuccinate and Idarubicin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and myeloid, and related phenotypes are juvenile myelomonocytic leukemia and Increased shRNA abundance (Z-score > 2)