Iron-Refractory Iron Deficiency Anemia, also known as irida syndrome, is related to microcytic anemia and iron deficiency anemia. An important gene associated with Iron-Refractory Iron Deficiency Anemia is TMPRSS6 (Transmembrane Serine Protease 6), and among its related pathways/superpathways is Hfe effect on hepcidin production. The drugs Iron and Sodium citrate have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related phenotypes are intellectual disability and ichthyosis