Immunodeficiency 14a with Lymphoproliferation, Autosomal Dominant (IMD14A)

Immunodeficiency 14a with Lymphoproliferation, Autosomal Dominant, also known as activated pi3k-delta syndrome, is related to immunodeficiency 36 with lymphoproliferation and immunodeficiency 14. An important gene associated with Immunodeficiency 14a with Lymphoproliferation, Autosomal Dominant is PIK3CD (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta), and among its related pathways/superpathways are PIP3 activates AKT signaling and PI3K-Akt signaling pathway. The drugs Temsirolimus and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related phenotypes are pneumonia and recurrent upper and lower respiratory tract infections