Immunodeficiency with Hyper-Igm, Type 4 (HIGM4)

Immunodeficiency with Hyper-Igm, Type 4, also known as hyper-igm syndrome type 4, is related to immunodeficiency with hyper-igm, type 3 and autoimmune lymphoproliferative syndrome. An important gene associated with Immunodeficiency with Hyper-Igm, Type 4 is UNG (Uracil DNA Glycosylase), and among its related pathways/superpathways are ERK Signaling and MIF Mediated Glucocorticoid Regulation. Affiliated tissues include lymph node, and related phenotypes are immunodeficiency and recurrent upper respiratory tract infections