Ichthyosis Hystrix, Curth-Macklin Type (IHCM)

Ichthyosis Hystrix, Curth-Macklin Type, also known as ichthyosis hystrix of curth-macklin, is related to ichthyosis and palmoplantar keratosis. An important gene associated with Ichthyosis Hystrix, Curth-Macklin Type is KRT1 (Keratin 1), and among its related pathways/superpathways are Keratinization and COPI-independent Golgi-to-ER retrograde traffic. Affiliated tissues include skin, and related phenotypes are ichthyosis and hyperkeratosis