Hypophosphatasia, Adult (HPPA)

Hypophosphatasia, Adult, also known as adult hypophosphatasia, is related to hypophosphatasia, infantile and hypophosphatasia, childhood. An important gene associated with Hypophosphatasia, Adult is ALPL (Alkaline Phosphatase, Biomineralization Associated), and among its related pathways/superpathways are Endochondral ossification with skeletal dysplasias and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Bortezomib and Rituximab have been mentioned in the context of this disorder. Affiliated tissues include bone and liver, and related phenotypes are carious teeth and rickets