Hereditary Spastic Paraplegia 35 (FAHN)

Hereditary Spastic Paraplegia 35, also known as autosomal recessive spastic paraplegia type 35, is related to spastic paraplegia 35, autosomal recessive, with or without neurodegeneration and lateral sclerosis, and has symptoms including ataxia, seizures and urgency of micturition. An important gene associated with Hereditary Spastic Paraplegia 35 is FA2H (Fatty Acid 2-Hydroxylase), and among its related pathways/superpathways are Autophagy and superpathway of coenzyme A biosynthesis III (mammals). The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include globus pallidus and brain, and related phenotypes are hyperreflexia and spastic paraplegia