Hereditary Periodic Fever Syndrome

Hereditary Periodic Fever Syndrome, also known as hereditary periodic fever syndromes, is related to familial cold autoinflammatory syndrome 2 and muckle-wells syndrome. An important gene associated with Hereditary Periodic Fever Syndrome is MEFV (MEFV Innate Immunity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and Colorectal Cancer Metastasis. Affiliated tissues include bone and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and liver/biliary system