Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related (UP-FTD)

GRN相关的额颞叶退变伴TDP43包涵体(来自ICD-11)

别称:

Primary Progressive Aphasia

Grn-Related Frontotemporal Lobar Degeneration with Tdp43 Inclusions

Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions

Frontotemporal Dementia, Ubiquitin-Positive

Mesulam Syndrome

Ppa

Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions, Susceptibility to

Tau-Negative Frontotemporal Dementia Linked to Chromosome 17

Frontotemporal Dementia with Tdp43 Inclusions, Grn-Related

Degeneration, Frontotemporal Lobar, with Tdp43 Inclusions

Aphasia, Primary Progressive, Susceptibility to

Dementia, Hereditary Dysphasic Disinhibition

Ubiquitin-Positive Frontotemporal Dementia

Aphasia, Primary Progressive

Aphasia Primary Progressive

Frontotemporal Dementia

Ftld-Tdp, Grn-Related

Up-Ftd

Ftldu

Ftdu

Hddd

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基础信息

疾病表征

基因 & 突变

靶点药物

疾病模型

文献报道

额颞叶萎缩伴 TDP-43 蛋白沉积，GRN 关联型，也被称为原发性进行性失语症，与 GRN 关联型额颞叶萎缩和进行性非流利失语症有关，症状包括性格改变、躁动和记忆力丧失。与额颞叶萎缩伴 TDP-43 蛋白沉积，GRN 关联型相关的基因是 GRN（前粒细胞生长因子原），其相关通路/超通路包括神经科学和铜稳态。在该疾病的背景下，已提到的药物包括美金刚和艾司西酞普兰。相关组织包括大脑和骨髓，相关表型为失语症和幻觉。

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