Facial Dysmorphism, Immunodeficiency, Livedo, and Short Stature (FILS)

Facial Dysmorphism, Immunodeficiency, Livedo, and Short Stature, also known as fils syndrome, is related to colorectal cancer 12 and sneddon syndrome, and has symptoms including flushing, icterus and pruritus. An important gene associated with Facial Dysmorphism, Immunodeficiency, Livedo, and Short Stature is POLE (DNA Polymerase Epsilon, Catalytic Subunit). Affiliated tissues include skin and b cells, and related phenotypes are decreased circulating total igm and short stature