Clubfoot, Congenital, with or Without Deficiency of Long Bones and/or Mirror-Image Polydactyly (CCF)

Clubfoot, Congenital, with or Without Deficiency of Long Bones and/or Mirror-Image Polydactyly, also known as familial clubfoot due to 5q31 microdeletion, is related to distal arthrogryposis and polydactyly. An important gene associated with Clubfoot, Congenital, with or Without Deficiency of Long Bones and/or Mirror-Image Polydactyly is PITX1 (Paired Like Homeodomain 1), and among its related pathways/superpathways is Ion channel transport. The drugs Clonidine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include bone and skeletal muscle, and related phenotypes are short stature and bilateral talipes equinovarus