Chronic Visceral Acid Sphingomyelinase Deficiency (NPD-B)

Chronic Visceral Acid Sphingomyelinase Deficiency, also known as niemann-pick disease type b, is related to niemann-pick disease, type c1 and anterior segment dysgenesis 1. An important gene associated with Chronic Visceral Acid Sphingomyelinase Deficiency is SMPD1 (Sphingomyelin Phosphodiesterase 1). The drugs Cyclophosphamide and Alemtuzumab have been mentioned in the context of this disorder. Affiliated tissues include liver and lung, and related phenotypes are osteopenia and splenomegaly