Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 (ALS-PDC1)

肌萎缩侧索硬化-帕金森-痴呆复合征1型(来自ICD-11)

别称:

Guam Disease

Lytico-Bodig Disease

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex of Guam

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, Susceptibility to

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex

Parkinson-Dementia Complex of Guam

Guam Parkinsonism-Dementia Complex

Als-Pdc

G-Pdc

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex, Susceptibility to

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia of Guam Syndrome

Sclerosis, Lateral, Amyotrophic/parkinsonism/dementia Complex 1

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Amyotrophic Lateral Sclerosis, Guam Form

Parkinsonism-Dementia-Als Complex

Amyotrophic Lateral Sclerosis

Parkinsonian Disorders

Als/pdc of Guam

Als-Pdc1

Pdals

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基础信息

疾病表征

基因 & 突变

靶点药物

疾病模型

文献报道

肌萎缩侧索硬化症-帕金森病/痴呆复合体1，也被称为关岛病，与额颞叶痴呆症/或肌萎缩侧索硬化症4和肌萎缩侧索硬化症19有关，症状包括震颤、运动迟缓和外锥体运动功能异常。与肌萎缩侧索硬化症-帕金森病/痴呆复合体1有关的重要基因是TRPM7（瞬时受体电位阳离子通道家族M成员7），其相关通路/超通路包括神经科学和铜稳态。在该疾病的背景下，奥氮平和利培酮已被提及。相关组织包括骨髓和脊髓，相关表型为脑萎缩和痴呆。

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