Amyotrophic Lateral Sclerosis Type 5, also known as amyotrophic lateral sclerosis 5, is related to amyotrophic lateral sclerosis type 6 and lateral sclerosis, and has symptoms including muscular fasciculation, muscle spasticity and abnormal pyramidal signs. An important gene associated with Amyotrophic Lateral Sclerosis Type 5 is SPG11 (SPG11 Vesicle Trafficking Associated, Spatacsin), and among its related pathways/superpathways are Cardiac conduction and MAPK-Erk Pathway. Affiliated tissues include spinal cord and endothelial.