Alexander Disease (ALXDRD)

Alexander Disease, also known as alexander's disease, is related to leukodystrophy and multiple system atrophy 1, and has symptoms including muscle spasticity and seizures. An important gene associated with Alexander Disease is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and GDNF signaling. The drug Metronidazole has been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related phenotypes are macrocephaly and intellectual disability