Alpha-2-Plasmin Inhibitor Deficiency (APLID)

Alpha-2-Plasmin Inhibitor Deficiency, also known as plasmin inhibitor deficiency, is related to hemorrhagic disease and severe pre-eclampsia. An important gene associated with Alpha-2-Plasmin Inhibitor Deficiency is SERPINF2 (Serpin Family F Member 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Affiliated tissues include whole blood and heart, and related phenotypes are bruising susceptibility and persistent bleeding after trauma