Alopecia Areata (AA)

Alopecia Areata, also known as pseudopelade, is related to alopecia and alopecia universalis congenita, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia Areata is AA1 (Alopecia Areata 1), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Acetylcysteine and Bimatoprost have been mentioned in the context of this disorder. Affiliated tissues include skin and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Synthetic lethal with MLN4924 (a NAE inhibitor)