Adult-Onset Still's Disease, also known as adult-onset still disease, is related to macrophage activation syndrome and juvenile rheumatoid arthritis, and has symptoms including exanthema An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways/superpathways are Infectious disease and ERK Signaling. The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node and bone, and related phenotypes are splenomegaly and hepatomegaly