Mouse
Hpd - 4-hydroxyphenylpyruvic acid dioxygenase
Alias:
Fla
Flp
Laf
Hppd
4HPPD
Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to act upstream of or within L-phenylalanine catabolic process. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in alimentary system; liver; musculature; and respiratory system. Used to study tyrosinemia type III. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
1
14
10917 bp
45.05
8
7
Hpd Genetics information (-)
GRCm39
Chr 5: 123309870 - 123320786
Adjacent gene of Hpd:6
Sequence Homology
Transcripts & Proteins
There are 1 transcripts and 1 protein isoforms for Hpd gene.
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
1
1400
14
1182
NP_032303.1
393
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Nervous system
Endocrine & Immune system
Respiratory & Circulatory system
Digestive system
Urinary & Reproductive system
Other systems
Interactions
Dir./Indir.
Active/Passive
Mechanism
Species
Tissue
Cells
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
图标
Quantity (Sta.)
Binding
Hpd
0
1
0.269
图标
Quantity (Des.)
Phosphorylation
Hpd
0
1
0.2
图标
Quantity (Des.)
Ubiquitination
Hpd
0
1
0.2
3 Results, 10 per Page
1
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available
References Literature
Numbers
Title
PMID
Journal
Year
IF
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
2010
64.5
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Molecular cell
2013
16
Large-scale phosphorylation analysis of mouse liver.
Proceedings of the National Academy of Sciences of the United States of America
2007
11.1
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome research
2004
7
Sequences of the mouse F protein alleles and identification of a T cell epitope.
European journal of immunology
1991
5.4
A nonsense mutation in the 4-hydroxyphenylpyruvic acid dioxygenase gene (Hpd) causes skipping of the constitutive exon and hypertyrosinemia in mouse strain III.
Genomics
1995
4.4
The transcriptional landscape of the mammalian genome.
Science (New York, N.Y.)
2005
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7 Results, 10 per Page
1
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Sequence
Comparison
Al agent
Sources
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