Yuan-Harel-Lupski Syndrome, also known as pmp22-rai1 contiguous gene duplication syndrome, is related to charcot-marie-tooth disease, demyelinating, type 1a and autism. An important gene associated with Yuan-Harel-Lupski Syndrome is YUHAL (Yuan-Harel-Lupski Syndrome). Affiliated tissues include spinal cord and heart, and related phenotypes are global developmental delay and delayed speech and language development