Amyotrophic Lateral Sclerosis 16, Juvenile, also known as amyotrophic lateral sclerosis type 16, is related to neuronopathy, distal hereditary motor, autosomal recessive 2 and distal spinal muscular atrophy 2, and has symptoms including muscle spasticity and upper motor neuron signs. An important gene associated with Amyotrophic Lateral Sclerosis 16, Juvenile is SIGMAR1 (Sigma Non-Opioid Intracellular Receptor 1), and among its related pathways/superpathways are Neuroscience and Inhibitory action of Lipoxins on Superoxide production in neutrophils. Affiliated tissues include spinal cord and brain, and related phenotypes are hyperreflexia and lower limb spasticity