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中文人类
MAP3K11 - Mitogen-activated Protein Kinase Kinase Kinase 11
Alias:
MLK3
PTK1
SPRK
MLK-3
MEKK11
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这个基因编码的蛋白质是丝氨酸/苏氨酸激酶家族的成员。这个激酶包含一个SH3结构域和一个亮氨酸拉链-基本基序。这个激酶优先激活MAPK8/JNK激酶，并作为JNK信号通路的正调节剂发挥作用。这个激酶可以直接磷酸化和激活IkappaB激酶α和β，并发现涉及由Rho家族GTPases和CDC42介导的NF-kappaB转录活性。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MAP3K11 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
