Enables PDZ domain binding activity. Involved in several processes, including calcium ion export; cellular response to lipid; and response to cold. Located in several cellular components, including basolateral plasma membrane; dendritic spine membrane; and neuronal cell body membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Biomarker of hypertension. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]