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中文人类
GAK - Cyclin G Associated Kinase
Alias:
DNAJ26
DNAJC26
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在所有真核生物中，细胞周期由细胞周期蛋白依赖的蛋白激酶（CDKs）调控，其活性受到细胞周期蛋白和CDK抑制剂的多种机制调控，涉及Ser、Thr或Tyr残基的磷酸化和去磷酸化的控制。细胞周期蛋白是具有称为“细胞周期蛋白盒”的共识结构的分子。在哺乳动物细胞中，已经识别出9种细胞周期蛋白，它们被称为细胞周期蛋白A到I。细胞周期蛋白G是p53肿瘤抑制基因产物的直接转录靶标，因此在p53下游发挥作用。GAK是细胞周期蛋白G和CDK5的关联伙伴。可选的剪接导致编码不同异构体的多种转录变异体。[RefSeq，2015年12月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
GAK Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
