Gene editing
Isl1tm1(cre)Tmj
Alias:
Isl1-Cre
Isl1cre
Isl1tm1(cre)Cos
Isl1-IRES-Cre
Isl-Cre
Islet1:Cre
Basic Information
An IRES-Cre-SV40pA cassette was inserted into the exon encoding the second LIM domain of Isl1. Endogenous regulatory sequences drive Cre expression in motor neurons and dorsal root and cranial sensory ganglia. (J:80963)
Basic Information
MGI ID
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Because of their genetic and physiological similarities with humans, mouse models are essential for understanding human illnesses. Advances in molecular biology and gene editing improve disease replication in mice, allowing researchers to get a better understanding of disease causes, identify biomarkers, and create treatments.
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References
Disease models are key instruments in biomedical research, and their literature reports are critical to the advancement of research. These publications provide researchers with a comprehensive theoretical foundation by detailing the design procedures, application regions, and outcomes analysis of disease models.
Title
PMID
Journal
Year
IF
