Abhd12 - abhydrolase domain containing 12

Enables acylglycerol lipase activity; lysophospholipase activity; and palmitoyl-(protein) hydrolase activity. Involved in cellular lipid catabolic process; protein depalmitoylation; and regulation of inflammatory response. Acts upstream of or within adult walking behavior; phosphatidylserine catabolic process; and response to auditory stimulus. Located in dendrite cytoplasm and endoplasmic reticulum membrane. Is integral component of membrane. Part of AMPA glutamate receptor complex. Used to study PHARC syndrome. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase). [provided by Alliance of Genome Resources, Apr 2022]