Abcc8 - ATP-binding cassette, sub-family C (CFTR/MRP), member 8

Predicted to enable ATPase-coupled cation transmembrane transporter activity; potassium channel activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in plasma membrane. Is expressed in cerebral cortex; foregut-midgut junction; heart ventricle; and retina inner nuclear layer. Used to study hyperinsulinemic hypoglycemia and transient neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]