Sel1l - sel-1 suppressor of lin-12-like (C. elegans)

Predicted to contribute to ubiquitin-protein transferase activity. Involved in ERAD pathway; protein secretion; and triglyceride metabolic process. Acts upstream of or within response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex and Hrd1p ubiquitin ligase ERAD-L complex. Is expressed in several structures, including genitourinary system; liver; neural tube; pancreas; and spleen. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]