Runx1 - runt related transcription factor 1

Enables DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of alpha-beta T cell differentiation; regulation of gene expression; and response to retinoic acid. Acts upstream of or within several processes, including animal organ development; behavioral response to pain; and nervous system development. Located in basement membrane and nucleus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]