Macf1 - microtubule-actin crosslinking factor 1

Enables actin binding activity and microtubule binding activity. Involved in several processes, including positive regulation of Wnt signaling pathway; regulation of focal adhesion assembly; and regulation of neuron projection arborization. Acts upstream of or within several processes, including Wnt signaling pathway; mesoderm formation; and posttranslational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm; cytoskeleton; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb segment; lung; and skeletal musculature. Human ortholog(s) of this gene implicated in lissencephaly 9 with complex brainstem malformation. Orthologous to human MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]