Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; protein K63-linked ubiquitination; and regulation of signal transduction. Is expressed in eye; ileum; male reproductive gland or organ; and nervous system. Orthologous to human PELI3 (pellino E3 ubiquitin protein ligase family member 3). [provided by Alliance of Genome Resources, Apr 2022]