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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Adamts12 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Alias:
ADAMTS-12
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个属于“去整合素和金属蛋白酶含血栓素主题模式”(ADAMTS)家族的多结构域基质相关金属内肽酶,这些酶在组织形态发生和病理生理重塑、炎症和血管生物学中具有多种作用。编码的前原原蛋白经历蛋白水解加工以产生活性蛋白酶。缺乏编码的蛋白质的小鼠在不同血管生成模型中表现出增强的血管生成反应和肿瘤侵袭性,以及在诱导结肠炎、内毒素性败血病和胰腺炎的实验条件下,表现出严重的炎症和恢复延迟。[由RefSeq,2016年7月提供]
Related ID:
NCBI:239337
ENSEMBL:ENSMUSG00000047497
UNIPROT:Q811B3
Basic Information
NCBI
Transcripts
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Length
MW (kDa)
Related Mouse Models
Reference
239337
4
24
284541 bp
177.77
6
8
Adamts12 Genetics information (+)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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