Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including cellular protein metabolic process; positive regulation of cellular protein metabolic process; and protein destabilization. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains). [provided by Alliance of Genome Resources, Apr 2022]