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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Adam12 - a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Alias:
Mltna
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个整合素和金属蛋白酶(ADAM)家族的成员,该家族在包括细胞信号传导、粘附和迁移等各种生物过程中扮演重要角色。编码的前原原蛋白经历蛋白水解加工,生成具有成熟功能并定位到细胞表面的蛋白质。约三分之一缺乏编码的蛋白质的小鼠在断奶前死亡。在杜氏肌营养不良症的小鼠模型中过表达编码的蛋白质可以通过防止细胞坏死和炎症来减轻肌肉病理。[RefSeq,2016年5月提供]
Related ID:
NCBI:11489
ENSEMBL:ENSMUSG00000054555
UNIPROT:Q61824
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
11489
1
23
341899 bp
98.50
3
5
Adam12 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
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* This data comes from NCBI.
Gene Expression
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Name
MGI
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