The targeting vector is designed to insert a loxP site upstream of exon 2, and an FRT-flanked PGK-neomycin cassette followed by a loxP-site downstream of exon 3. Cre-mediated recombination removed the neo cassette and exons 2-3. (J:343288)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count