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EN
Nucleotides were changed (CACCTG to GAATTC and ACTGTACACAGGTGTTCA to CAGTGCTAGCTTGCAGAC) in the ebox1 and ebox2 sequences of this intronic enhancer downstream of Thrb B2 isoform (ENSMUST00000022304)-specific alternative exon 1 in intron 4 (B2 intron 1). Initially, for selection purposes, a self-excising ACN cassette (loxP site + testis-specific ACE promoter driven cre gene + neomycin resistance gene cassette + loxP site) was inserted into intron 4. Subsequently, this cassette was self-deleted during breeding of chimeras, leaving only a single loxP site remaining at the boundary upstream of the enhancer (J:335506)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
