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CRISPR/Cas9 genome editing technology was used to generate an 11 bp deletion in the coding region of the third exon, 18 bp after the translation start site. Immunoblotting confirmed the absence of protein expression in white and brown adipose tissue of homozygous mutant mice, with no detectable compensation from other ApoL family members. (J:344362)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
