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EN
Tryptophan codon 2563 (TGG) and tyrosine codon 2565 (TAC) in exon 23 were changed to alanine (GCC, GCC) (ENSMUSP00000117651:p.W2563A, p.Y2565A) using an sgRNA (targeting GTGGTTCTACCATCCGG) and an ssODN template with CRISPR/Cas9 technology. The mutations are the equivalent of the human p.W2858A and p.Y2860A mutations and render the encoded peptide H3K9me3-binding-defective. (J:342966)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
