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The targeting vector is designed to insert a 158 kb (Chr4:89707185 - 89865027) fragment of the human SNCA carrying the A53T (alanine to threonine) mutation in place of Chr6:60683985-60848702 of the mouse Snca gene. The genomic sequences are from human assembly GRCh38.p14 and the mouse assembly GRCm39. The construct includes an loxP-flanked neomycin selection cassette. In addition, there is also a SNCA (non-coding antisense RNA) in the human genome segment. The insertion disrupts Snca transcription. Transient cre-medited recombination removed the neo cassette. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
