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The targeting vector is designed to insert a 65 kb (Chr1: 10989074 - 11054422) fragment of the human TARDBP (TAR DNA binding protein) in place of Chr4:148679229 - 148723697 of the mouse Tardbp gene. The genomic sequences are from human assembly GRCh38.p14 and the mouse assembly GRCm39. The insertion disrupts Tardbp transcription. The construct includes an loxP-flanked neomycin selection cassette. In addition, there is also a TARDBP (non-coding antisense RNA) in the human genome segment. Transient cre-mediated recombination removed the neo cassette. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
