Log In|Sign Up
EN
CRISPR/Cas9 technology replaced one of the cis-regulatory elements marked as DNase I-hypersensitive sites around the mouse Cbln2 locus designated as the Cbln2 enhancer E2 (1,005 bp) with the corresponding human CBLN2 enhancer E2 (chr18: 72,530,47372,531,324, GRCh38/hg38). Quantitative RT-PCR showed increased RNA expression of mouse Cbln2 in neonatal neocortex in homozygous mice. (J:331714)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
