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The targeting vector contains a CMV enhancer/chicken beta-actin core promoter (CAGGS), a loxP-STOP(6xSV40 polyA)-loxP cassette (LSL), an enhanced Acidaminococcus cas12a variant, including several substitutions (E174R/N282A/S542R/K548R; enAsCas12a), a nucleoplasmin nuclear localization signal (NLS), a 3xHA epitope sequence, an SV40 NLS and a rabbit beta-globin polyadenylation signal (RBG pA). Cre-mediated recombination removed the STOP cassette. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
