A linearized targeting vector is used to introduce an in-frame 2xMyc epitope tag to the 3' end of the gene. Cre-mediated recombination removed a loxP-flanked neomycin cassette in exon 8. (J:101977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count